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    <title>International Journal of Celiac Disease</title>
    <link>http://www.sciepub.com/journal/IJCD</link>
    <description>International Journal of Celiac Disease is an international scientific journal that publishes editorials, review article, short communications, original papers, case reports in English language. Journal publishes all works, that should be helpful in postgraduate educations of all professionals, who are interesting in celiac disease. Topics of the journal are problems of celiac disease and all of otherwise related texts in a broad of all medicine and other scientific fields. The main objective of Journal is publishing qualitative manuscripts with interesting information for clinical practice and for various researches. Editorial Board would like kindly invite all-world authors to send their manuscript for peer review. Journal is this time in the evaluation of some external databases with searching for IF.<br/><br/>All authors are responsible for submitting manuscripts in comprehensible US or UK English and ensuring scientific accuracy. International Journal of Celiac Disease subscribes to the <a href="http://www.wame.org/about/principles-of-transparency-and-best-practice"><b>Principles of Transparency and Best Practice in Scholarly Publishing</b></a> developed by The Committee on Publication Ethics (<a href="http://publicationethics.org/">COPE</a>), the Directory of Open Access Journals (<a href="http://www.doaj.org/">DOAJ</a>), the Open Access Scholarly Publishers Association (<a href="http://oaspa.org/">OASPA</a>), and the World Association of Medical Editors (<a href="http://www.wame.org/">WAME)</a>.<br/><br/>Manuscript format must be in accordance with the <a href="http://www.sciepub.com/icmje-recommendations.pdf">ICMJE-Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals</a>.</description>
    <dc:publisher>Science and Education Publishing</dc:publisher>
		<dc:language>en</dc:language>
		<dc:rights>2013 Science and Education Publishing Co. Ltd All rights reserved.</dc:rights>
		<prism:publicationName>International Journal of Celiac Disease</prism:publicationName>
		13
		1
		January 2025
		<prism:copyright>2013 Science and Education Publishing Co. Ltd All rights reserved.</prism:copyright>
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  <item rdf:about="http://pubs.sciepub.com/ijcd/13/1/1">
<title>
Ten Times Normal Anti Tissue Transglutaminase Level Detected By Enzyme Linked Immunosorbent Assay (ELISA), But Normal Level by Chemiluminescent Assay (CLIA)
</title>
<link>http://pubs.sciepub.com/ijcd/13/1/1</link>
<description>
<![CDATA[According to the new guidelines of the European Society for Pediatric Gastroenterology Hepatology and Nutrition [1], it is mandatory to test for anti tissue transglutaminase IgA (anti TTG IgA) and serum IgA in first step in the diagnosis of celiac disease. A diagnosis of celiac disease can be made when the anti-TTG IgA titer is ten times normal (with normal Ig A level) and anti-endomysial antibody (EMA) is positive in the second blood sample, without requiring biopsy. In this article, we present cases of anti TTG IgA levels more than ten times the upper limit of normal determined by ELISA (enzyme-linked immunosorbent assay). In some patients, EMA was checked and in all of these cases upper endoscopy and duodenal biopsy was performed for confirmation, Although biopsy was performed from the bulb and the second part of the duodenum, and the number of biopsies were adequate; no evidence of celiac disease was observed on histological examination. These patients were recruited, and another blood sample was taken and anti TTG IgA was checked by a chemiluminescence immunoassay (CLIA) and the levels were reported normal.]]>
</description>
<dc:creator>
Fatemeh  Elham Mahjoub, Mehrnaz  Farasat, Mehri  Najafi Sani, Azizollah  Yousefi, Pegah  Pakzadian, Fatemeh  Farahmand, Farzaneh  Moatamed, Pejman  Rohani, Shahindoqht  Homayoun Valiane, Alireza  Nourbakhsh, Touran  Akbari
</dc:creator>
<dc:date>2025-07-14</dc:date>
<dc:publisher>Science and Education Publishing</dc:publisher>
<prism:publicationDate>2025-07-14</prism:publicationDate>
<prism:number>1</prism:number>
<prism:volume>13</prism:volume>
<prism:startingPage>1</prism:startingPage>
<prism:endingPage>3</prism:endingPage>
<prism:doi>10.12691/ijcd-13-1-1</prism:doi>
</item>
<item rdf:about="http://pubs.sciepub.com/ijcd/13/1/2">
<title>
Mechanisms of Pathogenesis in Celiac Disease and Non-Celiac Gluten Sensitivity
</title>
<link>http://pubs.sciepub.com/ijcd/13/1/2</link>
<description>
<![CDATA[Celiac disease (CD) has in recent years become understood as a disease in which the importance of complete digestion of gliadin is essential for safe management of patients. Lately, the use of enzyme therapy for treatment of CD has gained wider acceptance as an adjunct to the gluten-free diet. A closer examination of Non-Celiac Gluten Sensitivity (NCGS) is warranted to determine if enzyme supplementation could be beneficial for individuals with this condition. Incomplete digestion of gluten produces toxic and/or immunologically active peptides which are implicated in both CD and in NCGS. These peptides are from a region close to the N-terminus of A-gliadin and contain serine or tyrosine residues. NCGS is caused by certain serine-containing peptides in A-gliadin and particularly those near the N-terminus. Peptide 11-19 is the most active of these peptides <i>in vitro</i> but may not be involved in cell-mediated immune reactions in CD. These reactions are related to tyrosine-containing peptides. Further along the chain is peptide 75-86, the most tissue damaging of the A-gliadin peptides in CD patients. This peptide is a tyrosine-containing peptide where damage caused to mucosal tissue is greater in CD than in NCGS. Hence, although CD and NCGS are both caused by gluten, the pathogenesis of the diseases has different mechanisms. However, both serine-containing and tyrosine-containing peptides are attacked by caricain, the protective enzyme in GluteGuard, thus rendering both types of toxic peptides harmless to the intestinal mucosa of susceptible individuals. Just as has been seen with Dermatitis Herpetiformis (DH), gluten is becoming a focus for several conditions when the neurological effects of gluten need to be considered.]]>
</description>
<dc:creator>
Hugh  J. Cornell, Teodor  Stelmasiak
</dc:creator>
<dc:date>2025-08-18</dc:date>
<dc:publisher>Science and Education Publishing</dc:publisher>
<prism:publicationDate>2025-08-18</prism:publicationDate>
<prism:number>1</prism:number>
<prism:volume>13</prism:volume>
<prism:startingPage>4</prism:startingPage>
<prism:endingPage>9</prism:endingPage>
<prism:doi>10.12691/ijcd-13-1-2</prism:doi>
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