http://www.sciepub.com/journal/AJCMR American Journal of Clinical Medicine Research is an international journal designed to be of wide range of interest and use to all those concerned with research in Clinical Medicine and their applications in research establishments, industry and universities. It publishes original papers, review articles related to all fields of aerospace research. Science and Education Publishing en 2013 Science and Education Publishing Co. Ltd All rights reserved. American Journal of Clinical Medicine Research 14 1 January 2026 2013 Science and Education Publishing Co. Ltd All rights reserved. http://pubs.sciepub.com/ajcmr/14/1/1 Dr. Sonal Ugalmugle, Dr. Lina Chaban, Dr. Archana Nimale, Dr. Manjiri Chakor, Dr. Sruthi Kalakota, Dr. Monica Milagros Parra Rodil, Dr. Sandeep Singh, Dr. Ridhi Bhola 2026-02-25 Science and Education Publishing 2026-02-25 1 14 1 7 10.12691/ajcmr-14-1-1 http://pubs.sciepub.com/ajcmr/14/1/2 Background: Dental implants are a predictable and highly successful treatment modality; however, their long-term success is closely influenced by the patient’s systemic health. As implant therapy is increasingly requested by medically compromised patients, understanding the impact of systemic conditions on implant outcomes is essential. Objective: This review aims to evaluate current evidence on the influence of systemic health conditions on dental implant success and to provide clinically relevant considerations for managing such patients. Methods: A literature search was conducted in PubMed, Scopus, and Embase, including clinical trials, cohort studies, and systematic reviews published over the past two decades that examined the relationship between systemic diseases and dental implant outcomes. Results: Several systemic conditions, including uncontrolled diabetes mellitus, cardiovascular disease, osteoporosis, obesity, autoimmune disorders, smoking, and chronic kidney or liver disease, were associated with impaired healing, compromised bone quality, and reduced implant stability. Additionally, medication-related factors such as bisphosphonate therapy and long-term immunosuppression were identified as contributing risks for implant-related complications. Conclusion: Systemic health status plays a critical role in dental implant success. Thorough medical evaluation, optimization of systemic conditions, and individualized treatment planning are essential to improve outcomes in medically compromised patients. Interdisciplinary collaboration and evidence-based decision-making are key to achieving safe and predictable implant therapy.]]> Dr. Deepthi Dandu, Dr. Urmi Reshamdalal, Dr. Irram Fatima, Dr. Syed Ammar Ali, Dr. Karen Michelle Izquierdo, Dr. Neha Sahu, Dr. Sandeep Singh 2026-03-04 Science and Education Publishing 2026-03-04 1 14 8 14 10.12691/ajcmr-14-1-2