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    <title>American Journal of Biomedical Research</title>
    <link>http://www.sciepub.com/journal/AJBR</link>
    <description>American Journal of Biomedical Research is a peer-reviewed, open access journal that provides rapid publication of articles in all areas of biomedical research. The goal of this journal is to provide a platform for scientists and academicians all over the world to promote, share, and discuss various new issues and developments in different areas of biomedical research.</description>
    <dc:publisher>Science and Education Publishing</dc:publisher>
		<dc:language>en</dc:language>
		<dc:rights>2013 Science and Education Publishing Co. Ltd All rights reserved.</dc:rights>
		<prism:publicationName>American Journal of Biomedical Research</prism:publicationName>
		13
		2
		January 2025
		<prism:copyright>2013 Science and Education Publishing Co. Ltd All rights reserved.</prism:copyright>
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<title>
Antiatherosclerotic Activities of Raphionacme brownii (Apocynaceae) Elliot-Scott on Rats
</title>
<link>http://pubs.sciepub.com/ajbr/13/2/1</link>
<description>
<![CDATA[Our study consisted of evaluating the antiatherosclerotic activity of Raphionacme brownii tubers. The antiatherosclerotic activities were evaluated on rats, subdivided into two phases including the induction of hypercholesterolemia for 30 days and the treatment of hypercholesterolemia for 15 days. The evaluation of the antiatherosclerotic activity revealed a significant decrease in TC to 44.28% in females and 47.98% in males; TG to 34.48% in females and 26.66% in males; LDL to 45.16% in females and 41.30% in males and conversely an increase in HDL to 14.58% in females and 20.75% in males. The atherogenic index showed a better activity of the effect of Raphionacme brownii tubers on atherosclerosis. The richness in bioactive compounds could justify the traditional use of Raphionacme brownii as a hypolipidemic agent treating cardiovascular diseases.]]>
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<dc:creator>
NGOUNBE  RILENGAR Léon, Hal Souakar  AMBERA, Kakesse  MAGUIRGUE, Brahim  Boy OTCHOM
</dc:creator>
<dc:date>2025-09-23</dc:date>
<dc:publisher>Science and Education Publishing</dc:publisher>
<prism:publicationDate>2025-09-23</prism:publicationDate>
<prism:number>2</prism:number>
<prism:volume>13</prism:volume>
<prism:startingPage>20</prism:startingPage>
<prism:endingPage>28</prism:endingPage>
<prism:doi>10.12691/ajbr-13-2-1</prism:doi>
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<title>
A Comprehensive Review of Laboratory Animals Use in Biomedical Research: Welfare Concerns and Alternative Approaches
</title>
<link>http://pubs.sciepub.com/ajbr/13/2/2</link>
<description>
<![CDATA[Laboratory animals have been central to biosciences research worldwide since decades. Animal welfare is increasingly being recognized as a critical component for both the ethical acceptability and scientific sustainability of such practices. Welfare entails preventing abuse, ensuring appropriate housing, feeding, disease prevention, treatment, and minimizing unnecessary discomfort or pain. The guiding principles of Replacement, Reduction, and Refinement (3Rs) not only improve welfare but also enhance translational value by increasing the reliability of animal models. Researchers bear ethical and legal obligations to safeguard animal well-being, as minimizing distress also improves reproducibility of results. The capacity of animals to adapt to their environment and exercise control over their lives is essential to welfare. Accordingly, animal experiments should be undertaken only when no alternative exists, and only when potential benefits outweigh the expected harm. Globally, millions of vertebrates are used each year in research, teaching, and testing. Approximately, 70% are employed in drug development, vaccine production, cancer research, and related biological studies, while the remaining 30% serve diagnostic and educational purposes. Among them, mice and rats dominate, accounting for about 61% and 14%, respectively, with rabbits also contributing significantly, particularly in atherosclerosis studies. Together, these species represent more than 80% of all research animals within the European Union. Harmonization of global laws and regulations remains essential to balance ethical responsibility with scientific progress. By promoting the 3Rs, reducing discomfort, and aligning practices with societal expectations, research can advance while maintaining respect for the animals on which it relies.]]>
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<dc:creator>
Mahendra  Pal, Tesfaye  Rebuma, Alemayehu  Bekele, Ravindra  Zende, Aishwarya  Nair, Dhwani  Upadhyay
</dc:creator>
<dc:date>2025-10-17</dc:date>
<dc:publisher>Science and Education Publishing</dc:publisher>
<prism:publicationDate>2025-10-17</prism:publicationDate>
<prism:number>2</prism:number>
<prism:volume>13</prism:volume>
<prism:startingPage>29</prism:startingPage>
<prism:endingPage>36</prism:endingPage>
<prism:doi>10.12691/ajbr-13-2-2</prism:doi>
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